Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

The DNA damage response (DDR) is a set of cellular events that follows the generation of DNA damage. Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNAs), have been shown to play a role in DDR signalling and DNA repair. Dysfunctional telomeres activate DDR in ageing, cancer and an increasing number of identified pathological conditions. Here we show that,...

Corrigendum: DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs

Molecular mechanisms by which oxidative DNA damage promotes telomerase activity

Telomeres are highly susceptible to oxidative DNA damage, which if left unrepaired can lead to dysregulation of telomere length homeostasis. Here we employed single molecule FRET, single molecule pull-down and biochemical analysis to investigate how the most common oxidative DNA lesions, 8-oxoguanine (8oxoG) and thymine glycol (Tg), regulate the structural properties of telomeric DNA and telome...

Quercetin Protects DNA from Oxidative Damage in Diabetics

Quercetin Protects DNA from Oxidative Damage in Diabetics Diabetics have reduced antioxidant defenses and an increased risk for free-radical mediated conditions such as heart disease and retinopathy. Quercetin, a dietary flavonoid with antioxidant properties, has been shown to protect retinal pigment epithelial and cortical cells during oxidative stress in vitro1, and to inhibit tyrosine kinase...

Thioredoxin 1 protects astrocytes from oxidative stress by maintaining peroxiredoxin activity

Previous studies have demonstrated that thioredoxin 1 (Trx1) exerts neuroprotective effects against cerebral ischemia/reperfusion injury caused by oxidative stress. While Trx1 is known to maintain the anti‑oxidant activity of 2‑Cys peroxiredoxins (Prdxs), the underlying mechanisms of its protective effects have remained to be elucidated, which was the aim of the present study. For this, an in v...